Cats Wiki

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Cats Wiki
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Hepatic lipidosis (HL), the most common acquired and potentially lethal feline liver disease, is a multifactorial syndrome. In most cases, a primary disease process causing anorexia sets the stage for HL in over-conditioned cats. Peripheral fat mobilization exceeding the hepatic capacity to either redistribute or use fat for β-oxidation (producing energy) leads to profound hepatocyte cytosolic expansion with triglyceride (fat) stores. In fewer cases, inappetence is caused by environmental stresses (eg, forced weight loss with unacceptable food substitutions, moving to a new household, newly introduced or loss of pets or family members, boarding, accidental confinement [eg, locked in a garage, basement, or attic], or an inside-only cat being lost outside). The term “idiopathic HL” is appropriate only when an underlying disease condition or event leading to inappetence cannot be identified

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