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Feline Hyperesthesia Syndrome, also known as rolling skin disease, is a rare illness in domestic cats that causes episodes of agitation, self-mutilation, and a characteristic rippling of the skin when touched. It is often described as a seizure disorder but the cause is unknown.

During an episode cats show a number of typical signs, including skin rolling or twitching, self-directed pouncing, or aggressive behavior such as biting or attacking the tail. There may also be pupil dilation, vocalisation and a general increase in activity.

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